Therapy Detail
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| Therapy Name | Cabazitaxel + ODM-208 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Cabazitaxel | Jevtana | XRP6258|RPR-116258A | Antimicrotubule Agent 14 | Jevtana (cabazitaxel) inhibits microtubule depolymerization by binding to tubulin, resulting in cell cycle arrest and decreased tumor cell proliferation (PMID: 32660451). |
| ODM-208 | ODM208|ODM 208|MK-5684|MK5684|MK 5684|Opevesostat | ODM-208 is a selective inhibitor of CYP11A1, which potentially inhibits steroid biosynthesis and tumor growth (PMID: 36129801). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06353386 | Phase Ib/II | ODM-208 ODM-208 + Olaparib Docetaxel + ODM-208 Cabazitaxel + ODM-208 | Substudy 01A: Safety and Efficacy of Opevesostat (MK-5684)-Based Treatment Combinations or Opevesostat Alone in Participants With Metastatic Castration-resistant Prostate Cancer (mCRPC) (MK-5684-01A) | Recruiting | USA | TUR | POL | NZL | ITA | ISR | IRL | GBR | FRA | FIN | ESP | DNK | DEU | CAN | AUS | 5 |
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