Therapy Detail
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| Therapy Name | Telisotuzumab adizutecan |
| Synonyms | |
| Therapy Description |
Telisotuzumab adizutecan (ABBV-400) is an antibody-drug conjugate (ADC) comprising an anti-MET monoclonal antibody conjugated to a topoisomerase inhibitor, which potentially inhibits tumor growth (Cancer Res (2023) 83 (7_Supplement): 6311). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Telisotuzumab adizutecan | ABBV 400|ABBV400|ABBV-400 | MET Antibody 37 | Telisotuzumab adizutecan (ABBV-400) is an antibody-drug conjugate (ADC) comprising an anti-MET monoclonal antibody conjugated to a topoisomerase inhibitor, which potentially inhibits tumor growth (Cancer Res (2023) 83 (7_Supplement): 6311). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06614192 | Phase III | Bevacizumab + Trifluridine-tipiracil hydrochloride Telisotuzumab adizutecan | A Study Assessing Adverse Events and Disease Activity When Comparing Intravenously (IV) Infused ABBV-400 to Trifluridine and Tipiracil (LONSURF) Oral Tablets Plus IV Infused Bevacizumab in Adult Participants With c-Met Protein Above Cutoff Level Above Refractory Metastatic Colorectal Cancer | Recruiting | USA | ISR | AUS | 4 |
| NCT05029882 | Phase I | Bevacizumab + Telisotuzumab adizutecan Telisotuzumab adizutecan Bevacizumab + Trifluridine-tipiracil hydrochloride | Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Advanced Solid Tumors Receiving Intravenous (IV) ABBV-400 as Monotherapy and in Combination With IV Bevacizumab | Active, not recruiting | USA | POL | ISR | FRA | ESP | AUS | 4 |
| NCT06084481 | Phase I | Itraconazole + Telisotuzumab adizutecan Telisotuzumab adizutecan | Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Select Advanced Solid Tumor Indications Receiving Intravenous (IV) ABBV-400 | Recruiting | USA | ISR | ESP | AUS | 4 |
| NCT07023289 | Phase II | Telisotuzumab adizutecan | A Study to Assess Adverse Events and Change in Disease Activity in Adult Participants Receiving Intravenously Infused Telisotuzumab Adizutecan Alone or With Standard of Care in Participants With Post Adjuvant Circulating Tumor DNA Positive Colorectal Cancer and No Radiographic Evidence of Disease | Recruiting | USA | ITA | ESP | DNK | 3 |
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