Therapy Detail
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| Therapy Name | Bevacizumab + Telisotuzumab adizutecan |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Bevacizumab | Avastin | VEGF Antibody 15 VEGFR Inhibitor (Pan) 36 | Avastin (bevacizumab) is a monoclonal antibody that binds VEGF and inhibits binding to VEGFR, potentially resulting in decreased tumor growth (PMID: 15136787). Avastin (bevacizumab) is FDA approved for use in colorectal cancer, non-small cell lung cancer, glioblastoma, renal cell carcinoma, cervical carcinoma, and ovarian cancer, and in combination with carboplatin and paclitaxel in epithelial ovarian, fallopian tube, or primary peritoneal cancer (FDA.gov). | |
| Telisotuzumab adizutecan | ABBV 400|ABBV400|ABBV-400 | MET Antibody 37 | Telisotuzumab adizutecan (ABBV-400) is an antibody-drug conjugate (ADC) comprising an anti-MET monoclonal antibody conjugated to a topoisomerase inhibitor, which potentially inhibits tumor growth (Cancer Res (2023) 83 (7_Supplement): 6311). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05029882 | Phase I | Bevacizumab + Telisotuzumab adizutecan Telisotuzumab adizutecan Bevacizumab + Trifluridine-tipiracil hydrochloride | Study to Assess Adverse Events and Change in Disease Activity in Adult Participants With Advanced Solid Tumors Receiving Intravenous (IV) ABBV-400 as Monotherapy and in Combination With IV Bevacizumab | Active, not recruiting | USA | POL | ISR | FRA | ESP | AUS | 4 |
| NCT06107413 | Phase II | Bevacizumab + Telisotuzumab adizutecan Bevacizumab + Fluorouracil + Leucovorin + Telisotuzumab adizutecan Bevacizumab + Fluorouracil + Irinotecan + Leucovorin | Study to Assess Adverse Events and Change in Disease Activity in Previously Treated Adult Participants Receiving Intravenous (IV) ABBV-400 With Unresectable Metastatic Colorectal Cancer in Combination With IV Fluorouracil, Folinic Acid, and Bevacizumab | Recruiting | USA | ISR | ESP | DEU | BEL | 3 |
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