Therapy Detail

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Therapy Name ANV419 + Ipilimumab
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ANV419 ANV 419|ANV-419 ANV419 is a fusion protein comprised of the cytokine IL-2 and an antibody that blocks the CD25 binding site of IL-2, which retains binding to CD122 and may lead to increased proliferation of CD8 T cells and NK cells and inhibition of tumor growth (Journal for ImmunoTherapy of Cancer 2021;9).
Ipilimumab Yervoy BMS-734016 CTLA4 Antibody 31 Immune Checkpoint Inhibitor 149 Yervoy (ipilimumab) is an antibody that binds to cytotoxic T-lymphocyte-associated antigen-4 (CTLA-4), causing increased T-cell activation (PMID: 28891423). Yervoy (ipilimumab) is FDA approved for use in patients with metastatic melanoma, including patients 12 years or older, and in combination with Opdivo (nivolumab) for intermediate or poor-risk renal cell carcinoma, microsatellite instability-high (MSI-H) or mismatch repair deficient (dMMR) metastatic colorectal cancer (including patients 12 years or older), hepatocellular carcinoma previously treated with Nexavar (sorafenib), in combination with Opdivo (nivolumab) as first-line therapy in patients with PD-L1-positive (>=1%) metastatic non-small cell lung cancer without EGFR or ALK alterations, and in combination with Opdivo (nivolumab) and platinum-based chemotherapy as first-line therapy in patients with metastatic or recurrent non-small cell lung cancer without EGFR or ALK alterations (FDA.gov).

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05578872 Phase Ib/II ANV419 + Ipilimumab ANV419 + Pembrolizumab ANV419 A Study of ANV419 Alone or in Combination With Approved Treatment in Patients With Cutaneous Melanoma (ANV419-101). Recruiting USA | ITA | FRA | ESP | DEU 0


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