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Drug Name ANV419
Trade Name
Synonyms ANV 419|ANV-419
Drug Descriptions

ANV419 is a fusion protein comprised of the cytokine IL-2 and an antibody that blocks the CD25 binding site of IL-2, which retains binding to CD122 and may lead to increased proliferation of CD8 T cells and NK cells and inhibition of tumor growth (Journal for ImmunoTherapy of Cancer 2021;9).

DrugClasses
CAS Registry Number NA
NCIT ID C180674

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Therapy Name Drugs Efficacy Evidence Clinical Trials
ANV419 ANV419 0 3
ANV419 + Daratumumab ANV419 Daratumumab 0 1
ANV419 + Dexamethasone + Lenalidomide ANV419 Dexamethasone Lenalidomide 0 1
ANV419 + Ipilimumab ANV419 Ipilimumab 0 1
ANV419 + Nivolumab ANV419 Nivolumab 0 0
ANV419 + Pembrolizumab ANV419 Pembrolizumab 0 1
ANV419 + tumor infiltrating lymphocytes ANV419 tumor infiltrating lymphocytes 0 1


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