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Therapy Name | PF-07799544 + PF-07799933 |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
PF-07799544 | PF 07799544|PF07799544|ARRY-134|ARRY 134|ARRY134 | MEK inhibitor (Pan) 26 | PF-07799544 is a brain-penetrant MEK inhibitor, which reduces downstream signaling and potentially decreases tumor cell proliferation (J Clin Oncol 42, 2024 (suppl 16; abstr 3154), NCI Drug Dictionary). | |
PF-07799933 | PF07799933|PF 07799933|ARRY440|ARRY 440|ARRY-440 | BRAF Inhibitor 25 | PF-07799933 inhibits BRAF mutations, including class 1, 2, and 3 mutations, which potentially leads to decreased downstream Erk signaling and inhibition of tumor growth (PMID: 38691346). |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT05538130 | Phase I | PF-07799544 Encorafenib + PF-07799544 PF-07284890 + PF-07799544 PF-07799544 + PF-07799933 | A Study to Learn About the Study Medicine Called PF-07799544 in People With Advanced Solid Tumors | Recruiting | USA | CAN | 0 |