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Therapy Name AOH1996
Synonyms
Therapy Description

AOH1996 targets PCNA and increases interaction with POLR2A, resulting in increased POLR2A degradation, and potentially leading to decreased DNA repair, increased replication stress and tumor cell apoptosis, and reduced tumor growth (PMID: 37531956).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AOH1996 AOH 1996|AOH-1996 AOH1996 targets PCNA and increases interaction with POLR2A, resulting in increased POLR2A degradation, and potentially leading to decreased DNA repair, increased replication stress and tumor cell apoptosis, and reduced tumor growth (PMID: 37531956).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06763341 Phase I AOH1996 + Azacitidine + Venetoclax AOH1996 + Venetoclax AOH1996 AOH1996 Alone or in Combination With Venetoclax With or Without Azacitidine for the Treatment of Patients With Relapsed or Refractory Acute Myeloid Leukemia Not yet recruiting USA 0
NCT05227326 Phase I AOH1996 AOH1996 for the Treatment of Refractory Solid Tumors Recruiting USA 0


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