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Therapy Name ACE1831 + Cyclophosphamide + Fludarabine + Obinutuzumab
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
ACE1831 ACE-1831|ACE 1831 ACE1831 is an antibody conjugated effector cell therapy comprising an anti-CD20 antibody conjugated to gamma delta T-lymphocytes, which potentially leads to tumor cell killing (Cancer Res 2022;82(12_Suppl):Abstract nr 5573).
Cyclophosphamide Cytoxan CPM Chemotherapy - Alkylating 18 Cytoxan (cyclophosphamide) is an alkylating agent, which inhibits DNA replication (NCI Drug Dictionary). Cytoxan (cyclophosphamide) is FDA approved in multiple hematological malignancies, breast cancer, neuroblastoma, ovarian cancer, and retinoblastoma (NCI Drug Dictionary).
Fludarabine Fludara FAMP|Fludarabine phosphate Flurdara (fludarabine) is converted to 2-fluoro-ara-ATP intracellularly, which potentially inhibits DNA polymerase alpha, ribonucleotide reductase and DNA primase, leading to decreased DNA synthesis and reduced tumor growth (NCI Drug Dictionary)
Obinutuzumab Gazyva R7159|afutuzumab|GA101|GA-101|RO 5072759 CD20 Antibody 24 Gazyva (obinutuzumab) is a glycoengineered anti-CD20 antibody that binds to CD20 on B-cells, resulting in increased antibody-dependent cellular cytotoxicity and induction of apoptosis, and potentially leading to decreased growth of B-cell tumors (PMID: 20194898, PMID: 21220500). Gazyva (obinutuzumab) is FDA approved in combination with Ambochlorin (chlorambucil) for chronic lymphocytic leukemia and in combination with Treanda (bendamustine) or chemotherapy for follicular lymphoma (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05653271 Phase I ACE1831 + Cyclophosphamide + Fludarabine + Obinutuzumab ACE1831 + Cyclophosphamide + Fludarabine ACE1831 in Adult Subjects With Relapsed/ Refractory CD20-expressing B-cell Malignancies Recruiting USA 1


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