Therapy Detail
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| Therapy Name | JBJ-04-125-02 + Mavelertinib |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| JBJ-04-125-02 | JBJ-04-125-02 is a next-generation allosteric EGFR inhibitor, which selectively inhibits the kinase activity and activation of EGFR L858R, resulting in reduced cell proliferation, increased apoptosis and tumor growth inhibition (PMID: 31092401). | |||
| Mavelertinib | PF-06747775 | EGFR Inhibitor 3rd gen 26 | Mavelertinib (PF-06747775) is a specific inhibitor of EGFR T790M, which causes cell death in EGFR T790M-positive tumor cells, while sparing wild-type EGFR (PMID: 30718357). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Case insensitive filtering will display rows if any text in any cell matches the filter term
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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