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Therapy Name AB-1015
Synonyms
Therapy Description

AB-1015 is an integrated circuit T (ICT) cell therapy that comprises T cells engineered to express a priming receptor that binds to ALPG/P and induces expression of a chimeric antigen receptor (CAR) that targets mesothelin (MSLN), as well as shRNA that targets FAS and PTPN2, potentially resulting in increased killing of ALPG/P and MSLN-expressing tumor cells (Cancer Res (2022) 82 (12_Supplement): 585).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AB-1015 AB 1015|AB1015 AB-1015 is an integrated circuit T (ICT) cell therapy that comprises T cells engineered to express a priming receptor that binds to ALPG/P and induces expression of a chimeric antigen receptor (CAR) that targets mesothelin (MSLN), as well as shRNA that targets FAS and PTPN2, potentially resulting in increased killing of ALPG/P and MSLN-expressing tumor cells (Cancer Res (2022) 82 (12_Supplement): 585).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05617755 Phase I AB-1015 AB-1015, an Integrated Circuit T (ICT) Cell Therapy in Patients With Platinum Resistant Epithelial Ovarian Cancer Active, not recruiting USA 0


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