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Therapy Detail
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| Therapy Name | AB-1015 |
| Synonyms | |
| Therapy Description |
AB-1015 is an integrated circuit T (ICT) cell therapy that comprises T cells engineered to express a priming receptor that binds to ALPG/P and induces expression of a chimeric antigen receptor (CAR) that targets mesothelin (MSLN), as well as shRNA that targets FAS and PTPN2, potentially resulting in increased killing of ALPG/P and MSLN-expressing tumor cells (Cancer Res (2022) 82 (12_Supplement): 585). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AB-1015 | AB 1015|AB1015 | AB-1015 is an integrated circuit T (ICT) cell therapy that comprises T cells engineered to express a priming receptor that binds to ALPG/P and induces expression of a chimeric antigen receptor (CAR) that targets mesothelin (MSLN), as well as shRNA that targets FAS and PTPN2, potentially resulting in increased killing of ALPG/P and MSLN-expressing tumor cells (Cancer Res (2022) 82 (12_Supplement): 585). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05617755 | Phase I | AB-1015 | AB-1015, an Integrated Circuit T (ICT) Cell Therapy in Patients With Platinum Resistant Epithelial Ovarian Cancer | Active, not recruiting | USA | 0 |
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