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Therapy Name	DS-1103a + Trastuzumab deruxtecan
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Therapy Description

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
DS-1103a		DS1103a\|DS 1103a	SIRPA Antibody 7	DS-1103a is an antibody that targets SIRPA and prevents its interaction with CD47, which potentially enhances macrophage-dependent anti-tumor activity (Journal for ImmunoTherapy of Cancer 2022, Vol 10: Suppl 2, 808).
Trastuzumab deruxtecan	Enhertu	DS-8201\|DS8201a\|T-DXd\|DS-8201\|fam-trastuzumab deruxtecan-nxki\|DS-8201a	HER2 (ERBB2) Antibody 78 HER2 (ERBB2) Antibody-Drug Conjugate 33	Enhertu (trastuzumab deruxtecan) is an antibody-drug conjugate (ADC) comprising an anti-ERBB2 (HER2) antibody linked to a derivative of the topoisomerase inhibitor DX-8951, which delivers the cytotoxic agent to ERBB2 (HER2)-expressing tumor cells, potentially resulting in decreased growth of tumors, including tumors with low ERBB2 (HER2) expression (PMID: 27026201). Enhertu (fam-trastuzumab deruxtecan-nxki) is FDA approved for use in patients with ERBB2 (HER2)-positive breast cancer who have received two or more anti-HER2 therapies previously, in patients with ERBB2 (HER2)-low (IHC 1+ or IHC 2+/ISH -) breast cancer received prior chemotherapy, in patients with ERBB2 (HER2)-low or untra-low (IHC 0 with membrane staining) hormone receptor-positive breast cancer who had received endocrine therapy, in patients with locally advanced or metastatic HER2-positive gastric or gastroesophageal (GEJ) adenocarcinoma who have received prior trastuzumab-based therapy, in patients with non-small cell lung cancer harboring ERBB2 (HER2) activating mutations who have received prior systemic therapy, and in patients with ERBB2 (HER2)-positive (IHC 3+) solid tumors who have received prior systemic therapy (FDA.gov).

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Clinical Trial	Phase	Therapies	Title	Recruitment Status	Covered Countries	Other Countries
NCT05765851	Phase I	DS-1103a + Trastuzumab deruxtecan	A Study of DS-1103a Combination Therapy in Participants With Advanced Solid Tumors	Active, not recruiting	USA \| FRA \| ESP \| CAN	0

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