Therapy Detail
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| Therapy Name | Carboplatin + Pemetrexed Disodium + Zimberelimab |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Carboplatin | Paraplatin | CBDCA | Chemotherapy - Platinum 7 | Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary). |
| Pemetrexed Disodium | Alimta | LY231514|Ciambra|pemetrexed | Chemotherapy - Antimetabolite 14 | Alimta (pemetrexed disodium) is an antifolate that inhibits thymidylate synthase (NCI Drug Dictionary). |
| Zimberelimab | GLS-010|AB122|AB-122|GLS010 | Immune Checkpoint Inhibitor 150 PD-L1/PD-1 antibody 132 | Zimberelimab (GLS-010) is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 28679395). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05633667 | Phase II | AB154 + Etrumadenant + Zimberelimab AB154 + Carboplatin + Pemetrexed Disodium + Zimberelimab AB154 + Carboplatin + Paclitaxel + Zimberelimab Etrumadenant + Sacituzumab govitecan-hziy + Zimberelimab Carboplatin + Paclitaxel + Zimberelimab Carboplatin + Nab-paclitaxel + Zimberelimab Docetaxel Etrumadenant + Zimberelimab Cisplatin + Pemetrexed Disodium + Zimberelimab Carboplatin + Pemetrexed Disodium + Zimberelimab Carboplatin + Nivolumab + Pemetrexed Disodium AB154 + Sacituzumab govitecan-hziy + Zimberelimab Sacituzumab govitecan-hziy + Zimberelimab Sacituzumab govitecan-hziy Carboplatin + Nivolumab + Paclitaxel | Study of Novel Treatment Combinations in Patients With Lung Cancer (VELOCITY-Lung) | Recruiting | USA | TUR | ISR | GBR | BRA | 3 |
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