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Therapy Name DZD8586
Synonyms
Therapy Description

DZD8586 is a non-covalent inhibitor of BTK and LYN that is blood-brain barrier-penetrant, which potentially induces tumor cell death and decreases tumor growth (Blood (2023) 142 (Supplement 1): 2822).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
DZD8586 DZD-8586|DZD 8586 BTK inhibitor 37 LYN Inhibitor 4 DZD8586 is a non-covalent inhibitor of BTK and LYN that is blood-brain barrier-penetrant, which potentially induces tumor cell death and decreases tumor growth (Blood (2023) 142 (Supplement 1): 2822).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05824585 Phase I DZD8586 DZD8586 in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma Recruiting USA | AUS 0


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