Therapy Detail
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| Therapy Name | DZD8586 |
| Synonyms | |
| Therapy Description |
DZD8586 is a non-covalent inhibitor of BTK and LYN that is blood-brain barrier-penetrant, which potentially induces tumor cell death and decreases tumor growth (Blood (2023) 142 (Supplement 1): 2822). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| DZD8586 | DZD-8586|DZD 8586 | BTK inhibitor 39 LYN Inhibitor 4 | DZD8586 is a non-covalent inhibitor of BTK and LYN that is blood-brain barrier-penetrant, which potentially induces tumor cell death and decreases tumor growth (Blood (2023) 142 (Supplement 1): 2822). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|---|---|---|---|---|---|---|
| BTK C481S | lymphoma | predicted - sensitive | DZD8586 | Preclinical - Cell culture | Actionable | In a preclinical study, DZD8586 inhibited proliferation of lymphoma cells expressing BTK C481S in culture (Blood (2023) 142 (Supplement 1): 2822). | detail... |
| BTK V416L | lymphoma | predicted - sensitive | DZD8586 | Preclinical - Cell culture | Actionable | In a preclinical study, DZD8586 inhibited proliferation of lymphoma cells expressing BTK V416L in culture (Blood (2023) 142 (Supplement 1): 2822). | detail... |
| BTK M437R BTK C481S | lymphoma | predicted - sensitive | DZD8586 | Preclinical - Cell culture | Actionable | In a preclinical study, DZD8586 inhibited proliferation of lymphoma cells expressing BTK M437R and BTK C481S in culture (Blood (2023) 142 (Supplement 1): 2822). | detail... |
| BTK L528W | lymphoma | predicted - sensitive | DZD8586 | Preclinical - Cell culture | Actionable | In a preclinical study, DZD8586 inhibited proliferation of lymphoma cells expressing BTK L528W in culture (Blood (2023) 142 (Supplement 1): 2822). | detail... |
| BTK M437R | lymphoma | predicted - sensitive | DZD8586 | Preclinical - Cell culture | Actionable | In a preclinical study, DZD8586 inhibited proliferation of lymphoma cells expressing BTK M437R in culture (Blood (2023) 142 (Supplement 1): 2822). | detail... |
| BTK C481F | lymphoma | predicted - sensitive | DZD8586 | Preclinical - Cell culture | Actionable | In a preclinical study, DZD8586 inhibited proliferation of lymphoma cells expressing BTK C481F in culture (Blood (2023) 142 (Supplement 1): 2822). | detail... |
| BTK A428D | lymphoma | predicted - sensitive | DZD8586 | Preclinical - Cell culture | Actionable | In a preclinical study, DZD8586 inhibited proliferation of lymphoma cells expressing BTK A428D in culture (Blood (2023) 142 (Supplement 1): 2822). | detail... |
| BTK C481Y | lymphoma | predicted - sensitive | DZD8586 | Preclinical - Cell culture | Actionable | In a preclinical study, DZD8586 inhibited proliferation of lymphoma cells expressing BTK C481Y in culture (Blood (2023) 142 (Supplement 1): 2822). | detail... |
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- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05824585 | Phase I | DZD8586 | DZD8586 in Patients With Relapsed or Refractory B-cell Non-Hodgkin Lymphoma | Completed | USA | AUS | 0 |
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