Therapy Detail
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| Therapy Name | Zoldonrasib |
| Synonyms | |
| Therapy Description |
Zoldonrasib (RMC-9805) inhibits KRAS G12D, which potentially results in reduced downstream signaling and proliferation, induction of apoptosis, and decreased tumor growth (Cancer Res 2023;83(7_Suppl):Abstract nr 526). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Zoldonrasib | RMC 9805|RMC9805|RMC-9805|RM036|RM-036|RM 036 | KRAS G12D Inhibitor 26 | Zoldonrasib (RMC-9805) inhibits KRAS G12D, which potentially results in reduced downstream signaling and proliferation, induction of apoptosis, and decreased tumor growth (Cancer Res 2023;83(7_Suppl):Abstract nr 526). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06162221 | Phase Ib/II | Daraxonrasib + Pembrolizumab + RMC-6291 Cisplatin + Daraxonrasib + Pembrolizumab + Pemetrexed Disodium + RMC-6291 Carboplatin + Daraxonrasib + Pembrolizumab + Pemetrexed Disodium Daraxonrasib + Pembrolizumab Cisplatin + Daraxonrasib + Pembrolizumab + Pemetrexed Disodium Zoldonrasib Cisplatin + Daraxonrasib + Pemetrexed Disodium + Zoldonrasib Carboplatin + Daraxonrasib + Pemetrexed Disodium + Zoldonrasib Carboplatin + Daraxonrasib + Pembrolizumab + Pemetrexed Disodium + RMC-6291 Daraxonrasib + Pembrolizumab + Zoldonrasib | Study of RAS(ON) Inhibitors in Patients With Advanced RAS-mutated NSCLC | Recruiting | USA | NLD | ITA | GRC | FRA | ESP | DNK | DEU | CZE | AUT | AUS | 2 |
| NCT06040541 | Phase I | Zoldonrasib | Study of RMC-9805 in Participants With KRAS G12D-Mutant Solid Tumors | Recruiting | USA | 0 |
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