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Therapy Name IOS-1002
Synonyms
Therapy Description

IOS-1002 is fusion protein comprising a modified version of HLA-B57 fused to IgG4 Fc, which targets the LILRB1 (ILT2), LILRB2 (ILT4), and KIR3DL1 receptors on immune cells and potentially increases antitumor immune response (PMID: 39199672).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
IOS-1002 IOS 1002|IOS1002 LILRB2 Antibody 11 IOS-1002 is fusion protein comprising a modified version of HLA-B57 fused to IgG4 Fc, which targets the LILRB1 (ILT2), LILRB2 (ILT4), and KIR3DL1 receptors on immune cells and potentially increases antitumor immune response (PMID: 39199672).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05763004 Phase I IOS-1002 IOS-1002 + unspecified PD-1 antibody A Clinical Study to Evaluate the Safety, Tolerability and Efficacy of IOS-1002 Administered Alone and in Combination With a PD-1 Monoclonal Antibody in Advanced Solid Tumors Recruiting AUS 0


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