Therapy Detail
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| Therapy Name | NT-175 |
| Synonyms | |
| Therapy Description |
NT-175 comprises autologous T-lymphocytes engineered to express an HLA-A*02:01-restricted T-cell receptor (TCR) targeting TP53 R175H, and to lack expression of TGFBR2, which potentially induces a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing TP53 R175H and inhibits tumor growth (J Clin Oncol 2024 42:16_suppl, 5011, NCI Drug Dictionary). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| NT-175 | NT175|NT 175 | NT-175 comprises autologous T-lymphocytes engineered to express an HLA-A*02:01-restricted T-cell receptor (TCR) targeting TP53 R175H, and to lack expression of TGFBR2, which potentially induces a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing TP53 R175H and inhibits tumor growth (J Clin Oncol 2024 42:16_suppl, 5011, NCI Drug Dictionary). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05877599 | Phase I | NT-175 | A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation | Recruiting | USA | 0 |
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