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Therapy Name NT-175
Synonyms
Therapy Description

NT-175 comprises autologous T-lymphocytes engineered to express an HLA-A*02:01-restricted T-cell receptor (TCR) targeting TP53 R175H, and to lack expression of TGFBR2, which potentially induces a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing TP53 R175H and inhibits tumor growth (J Clin Oncol 2024 42:16_suppl, 5011, NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
NT-175 NT175|NT 175 NT-175 comprises autologous T-lymphocytes engineered to express an HLA-A*02:01-restricted T-cell receptor (TCR) targeting TP53 R175H, and to lack expression of TGFBR2, which potentially induces a cytotoxic T-lymphocyte (CTL) response against tumor cells expressing TP53 R175H and inhibits tumor growth (J Clin Oncol 2024 42:16_suppl, 5011, NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05877599 Phase I NT-175 A Study of NT-175 in Adult Subjects With Unresectable, Advanced, and/or Metastatic Solid Tumors That Are Positive for HLA-A*02:01 and the TP53 R175H Mutation Recruiting USA 0


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