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Therapy Name TC-510
Synonyms
Therapy Description

TC-510 are autologous T-lymphocytes engineered to express both an anti-mesothelin (MSLN) antibody fused to the N-terminus of the CD3-epsilon subunit of the T-cell receptor complex as well as a PD-1:CD28 switch receptor, which potentially induce activation of T-lymphocytes, decrease PD-1/PD-L1 pathway-dependent T-cell suppression, and induce killing of tumor cells expressing MSLN (NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
TC-510 TC 510|TC510 MSLN Immune Cell Therapy 10 TC-510 are autologous T-lymphocytes engineered to express both an anti-mesothelin (MSLN) antibody fused to the N-terminus of the CD3-epsilon subunit of the T-cell receptor complex as well as a PD-1:CD28 switch receptor, which potentially induce activation of T-lymphocytes, decrease PD-1/PD-L1 pathway-dependent T-cell suppression, and induce killing of tumor cells expressing MSLN (NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05451849 Phase Ib/II Cyclophosphamide + Fludarabine TC-510 A Phase 1/2 Trial of TC-510 In Patients With Advanced Mesothelin-Expressing Cancer Active, not recruiting USA 0


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