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Therapy Name	PLM-101
Synonyms
Therapy Description	PLM-101 inhibits FLT3 and RET, potentially resulting increased cell cycle arrest and apoptosis and decreased tumor growth (PMID: 37392657).

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Drug Name	Trade Name	Synonyms	Drug Classes	Drug Description
PLM-101		PLM101\|PLM 101	FLT3 Antibody 5 RET Inhibitor 53	PLM-101 inhibits FLT3 and RET, potentially resulting increased cell cycle arrest and apoptosis and decreased tumor growth (PMID: 37392657).

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Molecular Profile	Indication/Tumor Type	Response Type	Therapy Name	Approval Status	Evidence Type	Efficacy Evidence	References
FLT3 exon 14 ins	acute myeloid leukemia	sensitive	PLM-101	Preclinical - Cell line xenograft	Actionable	In a preclinical study, PLM-101 induced apoptosis and cell cycle arrest and inhibited Flt3 phosphorylation, downstream signaling, and proliferation in acute myeloid leukemia cell lines harboring a FLT3-ITD mutation in culture and inhibited tumor growth in cell line xenograft models (PMID: 37392657).	37392657
FLT3 exon 14 ins	hematologic cancer	sensitive	PLM-101	Preclinical - Cell culture	Actionable	In a preclinical study, PLM-101 inhibited kinase activity and proliferation in cells expressing a FLT3-ITD mutation in culture (PMID: 37392657).	37392657
FLT3 exon 14 ins FLT3 D835Y	hematologic cancer	sensitive	PLM-101	Preclinical - Cell culture	Actionable	In a preclinical study, PLM-101 inhibited proliferation in cells expressing FLT3 D835Y in the context of a FLT3-ITD mutation in culture (PMID: 37392657).	37392657
FLT3 exon 14 ins FLT3 F691L	hematologic cancer	sensitive	PLM-101	Preclinical - Cell culture	Actionable	In a preclinical study, PLM-101 inhibited proliferation in cells expressing FLT3 F691L in the context of a FLT3-ITD mutation in culture (PMID: 37392657).	37392657

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