Therapy Detail
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| Therapy Name | DK210 |
| Synonyms | |
| Therapy Description |
DK210 is a dual cytokine fusion protein comprising high-affinity IL-10 linked to IL-2 by an anti-EGFR single chain variable fragment, which binds to EGFR and potentially induces a cytotoxic T-lymphocyte (CTL) response against tumor cells (J Clin Oncol 42, 2024 (suppl 16; abstr 2584), NCI Drug Dictionary). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| DK210 | DK-210|DK 210 | DK210 is a dual cytokine fusion protein comprising high-affinity IL-10 linked to IL-2 by an anti-EGFR single chain variable fragment, which binds to EGFR and potentially induces a cytotoxic T-lymphocyte (CTL) response against tumor cells (J Clin Oncol 42, 2024 (suppl 16; abstr 2584), NCI Drug Dictionary). |
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05704985 | Phase I | DK210 DK210 + Nivolumab Paclitaxel DK210 + Pembrolizumab Oxaliplatin Capecitabine Fluorouracil Carboplatin | Evaluating Safety and Biomarkers Using DK210 (EGFR) for Locally Advanced or Metastatic EGFR+ Tumors | Recruiting | USA | 0 |
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