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Therapy Name | A2B694 |
Synonyms | |
Therapy Description |
A2B694 are autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting MSLN, an LIR-1-based inhibitory receptor targeting HLA-A*02, and an shRNA targeting beta2 microglobulin, which may induce tumor killing and inhibit tumor growth (Journal for ImmunoTherapy of Cancer 2022;10). |