Therapy Detail
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| Therapy Name | BAY3546828 + Darolutamide |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| BAY3546828 | BAY 3546828|actinium-225-macropa-pelgifatamab|225Ac-pelgi|225Ac-pelgifatamab | PSMA Antibody 20 | BAY3546828 comprises a monoclonal antibody that targets PSMA linked to the radionuclide Actinium-225, which potentially inhibits tumor growth (Cancer Res (2023) 83 (7_Supplement): 5047). | |
| Darolutamide | Nubeqa | BAY1841788|ODM-201 | Hormone - Anti-androgens 54 | Nubeqa (darolutamide) is an androgen receptor antagonist that binds to and prevents nuclear translocation of the androgen receptor, thereby inhibiting expression of genes downstream of androgen receptor signaling that regulate proliferation of prostate cancer cells (PMID: 28490267). Nubeqa (darolutamide) is FDA approved for use in patients with non-metastatic castration-resistant prostate cancer, and in combination with docetaxel in patients with metastatic hormone-sensitive prostate cancer (FDA.gov). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|
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