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Therapy Name SAR445514
Synonyms
Therapy Description

SAR445514 is a trifunctional natural killer (NK) cell engager (NKCE) that binds to NKp46 and CD16a on NK cells leading to activation and redirects NK cells towards TNFRSF17 (BCMA)-expressing tumor cells, potentially resulting in increased tumor cell killing (Cancer Res (2023) 83 (7_Supplement): 2960).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
SAR445514 SAR 445514|SAR-445514|IPH 6401|IPH-6401|IPH6401|SAR514|SAR'514 SAR445514 is a trifunctional natural killer (NK) cell engager (NKCE) that binds to NKp46 and CD16a on NK cells leading to activation and redirects NK cells towards TNFRSF17 (BCMA)-expressing tumor cells, potentially resulting in increased tumor cell killing (Cancer Res (2023) 83 (7_Supplement): 2960).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05839626 Phase Ib/II SAR445514 A Study to Investigate Safety and Efficacy With SAR445514 in Participants With Relapsed/Refractory Multiple Myeloma (RRMM) and Relapsed/Refractory Light-chain Amyloidosis (RRLCA) Recruiting ITA | HUN | GBR | ESP | CZE | BEL | AUS 0


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