Therapy Detail
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| Therapy Name | KGX101 |
| Synonyms | |
| Therapy Description |
KGX101 is a prodrug comprising IL12 linked to an IL12RB-derived masking domain via a protease-sensitive linker that is cleaved by proteases in the tumor microenvironment, activating IL12 signaling and potentially stimulating an immune response and inhibiting tumor growth (Cancer Res (2024) 84 (6_Supplement): 4068). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| KGX101 | KGX-101|KGX 101 | KGX101 is a prodrug comprising IL12 linked to an IL12RB-derived masking domain via a protease-sensitive linker that is cleaved by proteases in the tumor microenvironment, activating IL12 signaling and potentially stimulating an immune response and inhibiting tumor growth (Cancer Res (2024) 84 (6_Supplement): 4068). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06074497 | Phase I | KGX101 | A Phase 1, First-in-Human of KGX101 to Patients With Advanced or Metastatic Solid Tumors | Active, not recruiting | AUS | 0 |
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