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Therapy Detail
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| Therapy Name | AZD5851 |
| Synonyms | |
| Therapy Description |
AZD5851 comprises T-cells engineered to express a chimeric antigen receptor (CAR) targeting GPC3 and a dominant negative TGF-beta type II receptor, which may inhibit tumor growth (J Immunol (2023) 210 (1_Supplement): 68.17) |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| AZD5851 | AZD-5851|AZD 5851|Autologous dnTGF-BRII-armored Anti-GPC3 CAR T-cells | AZD5851 comprises T-cells engineered to express a chimeric antigen receptor (CAR) targeting GPC3 and a dominant negative TGF-beta type II receptor, which may inhibit tumor growth (J Immunol (2023) 210 (1_Supplement): 68.17) |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06084884 | Phase Ib/II | AZD5851 | A Phase I/II Study to Evaluate AZD5851 in GPC3+ Advanced/Recurrent Hepatocellular Carcinoma (ATHENA) | Recruiting | USA | 2 |
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