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Therapy Name AZD5851
Synonyms
Therapy Description

AZD5851 comprises T-cells engineered to express a chimeric antigen receptor (CAR) targeting GPC3 and a dominant negative TGF-beta type II receptor, which may inhibit tumor growth (J Immunol (2023) 210 (1_Supplement): 68.17)

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Drug Name Trade Name Synonyms Drug Classes Drug Description
AZD5851 AZD-5851|AZD 5851|Autologous dnTGF-BRII-armored Anti-GPC3 CAR T-cells AZD5851 comprises T-cells engineered to express a chimeric antigen receptor (CAR) targeting GPC3 and a dominant negative TGF-beta type II receptor, which may inhibit tumor growth (J Immunol (2023) 210 (1_Supplement): 68.17)

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06084884 Phase Ib/II AZD5851 A Phase I/II Study to Evaluate AZD5851 in GPC3+ Advanced/Recurrent Hepatocellular Carcinoma (ATHENA) Recruiting USA 1


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