Therapy Detail
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| Therapy Name | TransCon IL-2 beta/gamma + TransCon TLR7/8 Agonist |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| TransCon IL-2 beta/gamma | TransCon IL-2b/g | TransCon IL-2 beta/gamma is a hydrogel based formulation of an IL-2 variant, which may lead to activation of cytotoxic T-lymphocytes and NK cells, and increased antitumor immune response, potentially resulting in tumor cell death (NCI Drug Dictionary). | ||
| TransCon TLR7/8 Agonist | Resiquimod Hydrogel-based Sustained-release formulation | TLR7 Agonist 13 TLR8 Agonist 10 | TransCon TLR7/8 Agonist is a hydrogel based formulation of an imidazoquinolinamine and resiquimod, which acts as an agonist of TLR 7 and TLR8, which potentially activates the antitumor immune response and may lead to tumor cell lysis (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05980598 | Phase II | Pembrolizumab + TransCon TLR7/8 Agonist TransCon IL-2 beta/gamma + TransCon TLR7/8 Agonist Pembrolizumab | TransCon (TC) TLR7/8 Agonist, TC IL-2 beta/gamma, Pembrolizumab Prior to Surgery for Advanced Head and Neck Squamous Cell Carcinoma (BelieveIT-201) | Terminated | USA | POL | ITA | HUN | ESP | DEU | 2 |
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