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Therapy Name JZP898
Synonyms
Therapy Description

JZP898 comprises IFNalpha2b linked to half-life extension domains by protease-sensitive linkers that are cleaved to in the presence of proteases in the tumor microenvironment to release IFNalpha2b, potentially inducing IFNalpha signaling and increased anti-tumor immune response (Cancer Res (2023) 83 (7_Supplement):1817).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
JZP898 JZP-898|JZP 898|WTX-613|WTX613 JZP898 comprises IFNalpha2b linked to half-life extension domains by protease-sensitive linkers that are cleaved to in the presence of proteases in the tumor microenvironment to release IFNalpha2b, potentially inducing IFNalpha signaling and increased anti-tumor immune response (Cancer Res (2023) 83 (7_Supplement):1817).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06108050 Phase I JZP898 + Pembrolizumab JZP898 JZP898 Intravenous Infusion as Monotherapy and Combination With Pembrolizumab in Adults With Advanced/Metastatic Solid Tumors Recruiting USA 0


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