Therapy Detail
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| Therapy Name | JNJ-87189401 + Pasritamig |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| JNJ-87189401 | JNJ 87189401|JNJ87189401 | CD28 Antibody 12 PSMA Antibody 22 | JNJ-87189401 is a bispecific antibody that targets PSMA on tumor cells and CD28 expressed on T-cells, which potentially induces T-cell activation and tumor cell death in PSMA-expressing tumors (Ann Oncol (2024) 35 (Suppl_2): S1000; NCI Drug Dictionary). | |
| Pasritamig | JNJ78278343|JNJ 78278343|JNJ-78278343 | CD3 Antibody 119 | Pasritamig (JNJ-78278343) is an IgG1 bispecific antibody that targets KLK2 on tumor cells and CD3 on T-lymphocytes, which may lead to T-lymphocyte activation and killing of tumor cells expressing KLK2 (PMID: 40450573). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06095089 | Phase I | JNJ-87189401 + Pasritamig | A Study of JNJ-87189401 Plus JNJ-78278343 for Advanced Prostate Cancer | Recruiting | USA | FRA | 0 |
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