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| Therapy Name | 177Lu-rhPSMA-10.1 |
| Synonyms | |
| Therapy Description |
177Lu-rhPSMA-10.1 is a radioconjugate comprising the radionuclide lutetium-177 linked to a PSMA-targeted ligand, PSMA-10.1, which delivers radiation to PSMA-expressing tumor cells, potentially resulting in increased tumor cell death and antitumor activity (PMID: 36692961, NCI Drug Dictionary). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| 177Lu-rhPSMA-10.1 | 177Lu rhPSMA-10.1|(177Lu) rhPSMA-10.1|Lutetium Lu 177 PSMA-10.1 | 177Lu-rhPSMA-10.1 is a radioconjugate comprising the radionuclide lutetium-177 linked to a PSMA-targeted ligand, PSMA-10.1, which delivers radiation to PSMA-expressing tumor cells, potentially resulting in increased tumor cell death and antitumor activity (PMID: 36692961, NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06059014 | Phase Ib/II | 177Lu-rhPSMA-10.1 | Phase I/II Study Evaluating PSMA Targeted Radionuclide Therapy in Adult Patients With Metastatic Clear Cell Renal Cancer (PRadR) | Recruiting | FRA | 0 |
| NCT05413850 | Phase Ib/II | 177Lu-rhPSMA-10.1 | Anti-tumour Activity of (177Lu) rhPSMA-10.1 Injection | Recruiting | USA | NLD | 0 |
| NCT06105918 | Phase I | 177Lu-rhPSMA-10.1 | Radioligand Therapy After PSMA PET Guided External Beam Radiotherapy for Treating Post-Prostatectomy Patients With Biochemically Recurrent Prostate Cancer | Recruiting | USA | 0 |
| NCT06401980 | Phase II | Docetaxel Radium Ra 223 dichloride 177Lu-rhPSMA-10.1 Darolutamide Olaparib Cabazitaxel | Darolutamide in Metastatic Castration-Resistant Prostate Cancer (mCRPC) | Recruiting | CHE | 0 |
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