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Therapy Name | EC1456 |
Synonyms | |
Therapy Description |
EC1456 is a small molecule drug comprised of folate (vitamin B9) linked to the cytotoxic agent, tubulysin B hydrazide, which is internalized by folate receptor-expressing tumor cells to inhibit microtubule polymerization thereby, inhibiting cell cycle progression and inducing apoptosis (PMID: 29895863, PMID: 32728172). |