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Therapy Name 177Lu-NeoB + Fulvestrant + Ribociclib
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
177Lu-NeoB lutetium neoB|177Lu-NeoBOMB1|Lutetium 177-NeoB 177Lu-NeoB is a radioconjugate comprising the radionuclide Lutetium-177 linked to the GRPR-antagonist NeoB (NeoBOMB1), which delivers radiation to GRPR-expressing tumor cells, potentially resulting in inhibition of tumor growth (PMID: 37640941, PMID: 27609789).
Fulvestrant Faslodex ICI 182,780 Hormone - Anti-estrogens 29 Faslodex (fulvestrant) is a competitive inhibitor of estrogen that binds and deforms estrogen receptors, and causes inhibition of growth in cultured estrogen-sensitive breast cancer cells and is FDA approved for use in patients with hormone receptor-positive breast cancer (FDA.gov).
Ribociclib Kisqali LEE011|LEE-011|LEE 011 CDK4/6 Inhibitor 14 Kisqali (ribociclib) is a dual CDK4/6 inhibitor, which may induce cell cycle arrest and reduce proliferation in cancer cells (PMID: 24045179). Kisqali (ribociclib) is FDA-approved in combination with an aromatase inhibitor in women with hormone receptor-positive, ERBB2 (HER2)-negative breast cancer, and in combination with Faslodex (fulvestrant) in postmenopausal women with hormone receptor-positive, ERBB2 (HER2)-negative breast cancer (FDA.gov).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05870579 Phase I 177Lu-NeoB + Fulvestrant + Ribociclib Goserelin [177Lu]Lu-NeoB in Combination With Ribociclib and Fulvestrant in Participants With ER+, HER2- and GRPR+ Advanced Breast Cancer Recruiting POL | FRA | ESP | DEU 1


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