Therapy Detail
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| Therapy Name | Cisplatin + Docetaxel + PRGN-2009 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Cisplatin | Platinol | CDDP | Chemotherapy - Platinum 7 | Platinol (cisplatin) is a platinum based chemotherapeutic, which is FDA approved for bladder, ovarian, and testicular cancers (NCI Drug Dictionary). |
| Docetaxel | Taxotere | RP56976 | Antimicrotubule Agent 14 | Taxotere (docetaxel) binds to tubulin, inhibiting microtubule disassembly and preventing cell division (PMID: 32496783, PMID: 32366558). |
| PRGN-2009 | PRGN2009|PRGN 2009 | PRGN-2009 consists of a gorilla adenovirus (GAd) that encodes agonistic HPV E6 and E7 epitopes, which potentially enhances antitumor immune response against HPV-positive tumors and reduces tumor growth (J Immunol 2020, 204 (1 Supplement) 91.6). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06223568 | Phase II | Cisplatin + Docetaxel Cisplatin + Docetaxel + PRGN-2009 | Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer | Recruiting | USA | 0 |
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