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Therapy Name Cisplatin + Docetaxel + PRGN-2009
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Cisplatin Platinol CDDP Chemotherapy - Platinum 7 Platinol (cisplatin) is a platinum based chemotherapeutic, which is FDA approved for bladder, ovarian, and testicular cancers (NCI Drug Dictionary).
Docetaxel Taxotere RP56976 Antimicrotubule Agent 14 Taxotere (docetaxel) binds to tubulin, inhibiting microtubule disassembly and preventing cell division (PMID: 32496783, PMID: 32366558).
PRGN-2009 PRGN2009|PRGN 2009 PRGN-2009 consists of a gorilla adenovirus (GAd) that encodes agonistic HPV E6 and E7 epitopes, which potentially enhances antitumor immune response against HPV-positive tumors and reduces tumor growth (J Immunol 2020, 204 (1 Supplement) 91.6).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06223568 Phase II Cisplatin + Docetaxel Cisplatin + Docetaxel + PRGN-2009 Phase II Trial of Neoadjuvant Chemotherapy (NAC) Alone or in Combination With Immunotherapy Vaccine PRGN-2009 in Subjects With Newly Diagnosed HPV-Associated Oropharyngeal (Head and Neck) Cancer Recruiting USA 0


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