Therapy Detail
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| Therapy Name | NT-112 |
| Synonyms | |
| Therapy Description |
NT-112 comprises autologous T lymphocytes engineered to express an HLA-C*08:02-restricted T-cell receptor (TCR) targeting KRAS G12D, which potentially induces cytotoxic T-lymphocyte (CTL)-dependent killing of tumor cells expressing KRAS G12D and inhibits tumor growth (Clin Oncol 42, 2024 (suppl 16; e14533, NCI Drug Dictionary). |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| NT-112 | NT112|NT 112 | NT-112 comprises autologous T lymphocytes engineered to express an HLA-C*08:02-restricted T-cell receptor (TCR) targeting KRAS G12D, which potentially induces cytotoxic T-lymphocyte (CTL)-dependent killing of tumor cells expressing KRAS G12D and inhibits tumor growth (Clin Oncol 42, 2024 (suppl 16; e14533, NCI Drug Dictionary). |
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06218914 | Phase I | AZD0240 NT-112 | Phase 1 Study to Investigate TCRTs KRAS Mutation in Unresectable, Advanced, and/or Metastatic Solid Tumors | Recruiting | USA | 0 |
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