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Therapy Name | NT-112 |
Synonyms | |
Therapy Description |
NT-112 comprises autologous T lymphocytes engineered to express an HLA-C*08:02-restricted T-cell receptor (TCR) targeting KRAS G12D, which potentially induces cytotoxic T-lymphocyte (CTL)-dependent killing of tumor cells expressing KRAS G12D and inhibits tumor growth (Clin Oncol 42, 2024 (suppl 16; e14533, NCI Drug Dictionary). |