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Therapy Name TmPSMA-02 CAR-T cells
Synonyms
Therapy Description

TmPSMA-02 CAR T-cells are autologous T-lymphocytes engineered to express a CD2 endodomain-containing chimeric antigen receptor (CAR) targeting PSMA, a dominant negative form of TGFBR2, and a PD-1:CD28 switch receptor linked to the co-stimulatory domains of CD28, which may induce toxicity against PSMA-expressing tumor cells (J of Clin Oncol 40, no. 6_suppl (February 16, 2022) 158, NCI Drug Dictionary).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
TmPSMA-02 CAR-T cells TmPSMA 02|TmPSMA-02 TmPSMA-02 CAR-T cells are autologous T-lymphocytes engineered to express a CD2 endodomain-containing chimeric antigen receptor (CAR) targeting PSMA, a dominant negative form of TGFBR2, and a PD-1-CD28 switch receptor, which may induce toxicity against PSMA-expressing tumor cells (J Clin Oncol 40, no. 6_suppl (February 16, 2022) 158, NCI Drug Dictionary).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06046040 Phase I TmPSMA-02 CAR-T cells TmPSMA-02 in mCRPC Recruiting USA 0


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