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Therapy Name | TmPSMA-02 CAR-T cells |
Synonyms | |
Therapy Description |
TmPSMA-02 CAR-T cells are autologous T-lymphocytes engineered to express a CD2 endodomain-containing chimeric antigen receptor (CAR) targeting PSMA, a dominant negative form of TGFBR2, and a PD-1-CD28 switch receptor, which may induce toxicity against PSMA-expressing tumor cells (J Clin Oncol 40, no. 6_suppl (February 16, 2022) 158, NCI Drug Dictionary). |