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Therapy Name TUB-040
Synonyms
Therapy Description

TUB-040 is an antibody-drug conjugate (ADC) comprising an antibody targeting SLC34A2 (NAPI2B) linked to a topoisomerase 1 inhibitor, which induces DNA damage and apoptosis, potentially resulting in tumor growth inhibition (Cancer Res (2024) 84 (6_Supplement): 2622).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
TUB-040 TUB040|TUB 040 TUB-040 is an antibody-drug conjugate (ADC) comprising an antibody targeting SLC34A2 (NAPI2B) linked to a topoisomerase 1 inhibitor, which induces DNA damage and apoptosis, potentially resulting in tumor growth inhibition (Cancer Res (2024) 84 (6_Supplement): 2622).

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06303505 Phase Ib/II TUB-040 FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Patients With PROC or r/r Adenocarcinoma NSCLC (NAPISTAR1-01) Recruiting USA | ESP | DEU | BEL 1


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