Therapy Detail
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| Therapy Name | Bevacizumab + TUB-040 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Bevacizumab | Avastin | VEGF Antibody 17 VEGFR Inhibitor (Pan) 36 | Avastin (bevacizumab) is a monoclonal antibody that binds VEGF and inhibits binding to VEGFR, potentially resulting in decreased tumor growth (PMID: 15136787). Avastin (bevacizumab) is FDA approved for use in colorectal cancer, non-small cell lung cancer, glioblastoma, renal cell carcinoma, cervical carcinoma, and ovarian cancer, and in combination with carboplatin and paclitaxel in epithelial ovarian, fallopian tube, or primary peritoneal cancer (FDA.gov). | |
| TUB-040 | TUB040|TUB 040 | TUB-040 is an antibody-drug conjugate (ADC) comprising an antibody targeting SLC34A2 (NAPI2B) linked to a topoisomerase 1 inhibitor, which induces DNA damage and apoptosis, potentially resulting in tumor growth inhibition (Cancer Res (2024) 84 (6_Supplement): 2622). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06303505 | Phase Ib/II | Bevacizumab + TUB-040 TUB-040 | FiH Study to Investigate Safety, PK and Efficacy of the NaPi2b ADC TUB-040 in Patients With PROC or r/r Adenocarcinoma NSCLC (NAPISTAR1-01) | Recruiting | USA | ROU | GBR | ESP | DEU | BEL | 1 |
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