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Therapy Name Autologous CXCR2-modified CD70 CAR-T cells
Synonyms
Therapy Description

Autologous CXCR2 modified CD70 CAR-T cells are autologous T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting CD70 and expressing the IL-8 receptor CXCR2, which may relieve tumor immunosuppression and inhibit tumor growth (PMID: 31488817).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Autologous CXCR2-modified CD70 CAR-T cells autologous 8R-70CAR T-cells|autologous IL-8RB-modified CD70-CAR T-cells Autologous CXCR2-modified CD70 CAR-T cells are autologous T-lymphocytes engineered to express the IL-8 receptor CXCR2 and a chimeric antigen receptor (CAR) targeting CD70, which may increase antitumor immune response and inhibit tumor growth (PMID: 31488817).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05353530 Phase I Autologous CXCR2-modified CD70 CAR-T cells Phase I Study of IL-8 Receptor-modified CD70 CAR T Cell Therapy in CD70+ Adult Glioblastoma (IMPACT) (IMPACT) Recruiting USA 0


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