Therapy Detail
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| Therapy Name | Axitinib + INCB099280 |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Axitinib | Inlyta | AG-013736|AG013736 | KIT Inhibitor 57 PDGFR Inhibitor (Pan) 30 VEGFR Inhibitor (Pan) 36 | Inlyta (axitinib) inhibits the VEGFRs, PDGFR, and KIT, potentially resulting in decreased angiogenesis and reduced tumor growth (PMID: 16027439, PMID: 25709499). Inlyta (axitinib) is approved for renal cell carcinoma (FDA.gov). |
| INCB099280 | INCB 099280|INCB-099280|INCB 99280|INCB-99280|INCB99280 | Immune Checkpoint Inhibitor 150 PD-L1 Inhibitor 15 | INCB099280 is a small molecule inhibitor of CD274 (PD-L1) that prevents binding to PDCD1 (PD-1), potentially inducing an anti-tumor immune response (J ImmunoTherapy Cancer 2022;10, NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05949632 | Phase Ib/II | Axitinib + INCB099280 | A Study of INCB099280 in Combination With Axitinib in Adults With Advanced Solid Tumors | Terminated | GBR | 0 |
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