Therapy Detail
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| Therapy Name | ABBV-151 + Budigalimab + Pemetrexed Disodium |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ABBV-151 | ARGX-115|ABBV151|ABBV 151|ARGX 115|ARGX-115|ARGX115|Livmoniplimab | ABBV-151 is a monoclonal antibody that targets the glycoprotein A repetitions predominant (GARP)-transforming growth factor beta 1 (TGFbeta1) complex, which prevents release of active TGF-beta1, potentially leading to antitumor activity (Journal for ImmunoTherapy of Cancer 2022;10). | ||
| Budigalimab | ABBV181|ABBV 181|ABBV-181 | Immune Checkpoint Inhibitor 149 PD-L1/PD-1 antibody 121 | Budigalimab is a monoclonal antibody that targets PD-1 (PDCD1) and inhibits binding of the PD-L1 (CD274) ligand, potentially resulting in enhanced anti-tumor immune response (PMID: 32770720). | |
| Pemetrexed Disodium | Alimta | LY231514|Ciambra|pemetrexed | Chemotherapy - Antimetabolite 14 | Alimta (pemetrexed disodium) is an antifolate that inhibits thymidylate synthase (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06236438 | Phase II | ABBV-151 + Budigalimab + Cisplatin + Pemetrexed Disodium Budigalimab + Carboplatin + Pemetrexed Disodium Cisplatin + Pembrolizumab + Pemetrexed Disodium ABBV-151 + Budigalimab + Carboplatin + Pemetrexed Disodium ABBV-151 + Budigalimab + Pemetrexed Disodium Budigalimab + Cisplatin + Pemetrexed Disodium Carboplatin + Pembrolizumab + Pemetrexed Disodium | Study to Evaluate Adverse Events, Optimal Dose, and Change in Disease Activity, With Livmoniplimab in Combination With Budigalimab Plus Chemotherapy Versus IV Infused Pembrolizumab Plus Chemotherapy in Adult Participants With Untreated Metastatic Non-Squamous Non-Small Cell Lung Cancer (NSCLC) (LIVIGNO-4) | Recruiting | USA | TUR | ISR | AUS | 3 |
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