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Therapy Name NST-628
Synonyms
Therapy Description

NST-628 stabilizes the RAF-MEK complex, which inhibits MEK/ERK/RSK phosphorylation and reactivation of the pathway, potentially leading to tumor growth inhibition (PMID: 38588399).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
NST-628 NST628|NST 628 MEK inhibitor (Pan) 26 RAF Inhibitor (Pan) 28 NST-628 stabilizes the RAF-MEK complex, which inhibits MEK/ERK/RSK phosphorylation and reactivation of the pathway, potentially leading to tumor growth inhibition (PMID: 38588399).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
BRAF G469E NRAS G13V melanoma sensitive NST-628 Preclinical - Pdx Actionable In a preclinical study, NST-628 treatment resulted in an overall response rate of 69.5% in a panel of patient-derived xenograft (PDX) models of solid tumors harboring RAS-MAPK pathway alterations, including a response in a melanoma patient-derived xenograft (PDX) model harboring BRAF G469E and NRAS G13V (PMID: 38588399). 38588399
BRAF D594N lung adenocarcinoma predicted - sensitive NST-628 Preclinical - Pdx Actionable In a preclinical study, NST-628 treatment resulted in an overall response rate of 69.5% in a panel of patient-derived xenograft (PDX) models of solid tumors harboring RAS-MAPK pathway alterations, including 1 response out of 2 lung adenocarcinoma patient-derived xenograft (PDX) models harboring BRAF D594N (PMID: 38588399). 38588399
BRAF G469A lung sarcomatoid carcinoma sensitive NST-628 Preclinical - Pdx Actionable In a preclinical study, NST-628 treatment resulted in an overall response rate of 69.5% in a panel of patient-derived xenograft (PDX) models of solid tumors harboring RAS-MAPK pathway alterations, including a response in a lung sarcomatoid carcinoma patient-derived xenograft (PDX) model harboring BRAF G469A (PMID: 38588399). 38588399
BRAF D594E HRAS Q61L melanoma sensitive NST-628 Preclinical - Pdx Actionable In a preclinical study, NST-628 treatment resulted in an overall response rate of 69.5% in a panel of patient-derived xenograft (PDX) models of solid tumors harboring RAS-MAPK pathway alterations, including a response in a melanoma patient-derived xenograft (PDX) model harboring BRAF D594E and HRAS Q61L (PMID: 38588399). 38588399
NRAS Q61L melanoma sensitive NST-628 Preclinical - Cell line xenograft Actionable In a preclinical study, NST-628 inhibited viability of a melanoma cancer cell line harboring NRAS Q61L in culture and inhibited tumor growth and induced tumor regression in a cell line xenograft model (PMID: 38588399). 38588399
NRAS Q61R melanoma sensitive NST-628 Preclinical - Cell line xenograft Actionable In a preclinical study, NST-628 inhibited viability of a melanoma cancer cell line harboring NRAS Q61R in culture and induced tumor regression in an intracranial cell line xenograft model (PMID: 38588399). 38588399

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06326411 Phase I NST-628 A Study to Investigate the Safety and Efficacy of NST-628 Oral Tablets in Subjects With Solid Tumors (NST-628) Recruiting USA | AUS 0


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