NST-628
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| Drug Name | NST-628 |
| Trade Name | |
| Synonyms | NST628|NST 628 |
| Drug Descriptions |
NST-628 stabilizes the RAF-MEK complex, which inhibits MEK/ERK/RSK phosphorylation and reactivation of the pathway, potentially leading to tumor growth inhibition (PMID: 38588399). |
| DrugClasses | MEK inhibitor (Pan) 27 RAF Inhibitor (Pan) 29 |
| CAS Registry Number | 3002056-30-3 |
| NCIT ID | NA |
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| Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
|---|---|---|---|
| Adagrasib + NST-628 | Adagrasib NST-628 | 0 | 0 |
| NST-628 | NST-628 | 6 | 1 |
| NST-628 + Osimertinib | NST-628 Osimertinib | 0 | 0 |
| NST-628 + Sotorasib | NST-628 Sotorasib | 0 | 0 |
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