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Drug Name | NST-628 |
Trade Name | |
Synonyms | NST628|NST 628 |
Drug Descriptions |
NST-628 stabilizes the RAF-MEK complex, which inhibits MEK/ERK/RSK phosphorylation and reactivation of the pathway, potentially leading to tumor growth inhibition (PMID: 38588399). |
DrugClasses | MEK inhibitor (Pan) 26 RAF Inhibitor (Pan) 28 |
CAS Registry Number | 3002056-30-3 |
NCIT ID | NA |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Adagrasib + NST-628 | Adagrasib NST-628 | 0 | 0 |
NST-628 | NST-628 | 6 | 1 |
NST-628 + Sotorasib | NST-628 Sotorasib | 0 | 0 |