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Drug Name NST-628
Trade Name
Synonyms NST628|NST 628
Drug Descriptions

NST-628 stabilizes the RAF-MEK complex, which inhibits MEK/ERK/RSK phosphorylation and reactivation of the pathway, potentially leading to tumor growth inhibition (PMID: 38588399).

DrugClasses MEK inhibitor (Pan) 26 RAF Inhibitor (Pan) 28
CAS Registry Number 3002056-30-3
NCIT ID NA

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Adagrasib + NST-628 Adagrasib NST-628 0 0
NST-628 NST-628 6 1
NST-628 + Sotorasib NST-628 Sotorasib 0 0


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