Therapy Detail
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| Therapy Name | ACLX-001 + CART-ddBCMA |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| ACLX-001 | ACLX001|ACLX 001 | TNFRSF17 Immune Cell Therapy 27 | ACLX-001 is a cell therapy comprising SPRX-001, a soluble protein targeting TNFRSF17 (BCMA), and Antigen Receptor Complex T-cells (ARC T-cells), which potentially induces antitumor activity (Cancer Res (2021) 81 (13_Supplement): 1549). | |
| CART-ddBCMA | Anitocabtagene autoleucel | TNFRSF17 Immune Cell Therapy 27 | CART-ddBCMA are autologous T-lymphocytes that have been engineered to express a chimeric antigen receptor (CAR) with a synthetic antigen-binding domain targeting BCMA (TNFRSF17) and containing CD137 (4-1BB) and CD3 zeta signaling domains, which potentially have antitumor activity (PMID: 35468618). |
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- Case insensitive filtering will display rows if any text in any cell matches the filter term
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- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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- Click on any column header arrows to sort by that column
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
Filtering
- Case insensitive filtering will display rows if any text in any cell matches the filter term
- Use simple literal full or partial string matches
- Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
- Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
Sorting
- Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
- Click on any column header arrows to sort by that column
- Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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