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| Therapy Name | TSC-200-A0201 |
| Synonyms | |
| Therapy Description |
TSC-200-A0201 comprises autologous T-cells engineered to express a T-cell receptor (TCR) targeting the HPV16 E7 antigen presented on HLA-A*02:01, which potentially inhibit growth of HPV16 E7-expressing tumors (Journal for ImmunoTherapy of Cancer 2023;11). |
| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| TSC-200-A0201 | TSC 200-A0201|TSC200-A0201 | TSC-200-A0201 comprises autologous T-cells engineered to express a T-cell receptor (TCR) targeting the HPV16 E7 antigen presented on HLA-A*02:01, which potentially inhibit growth of HPV16 E7-expressing tumors (Journal for ImmunoTherapy of Cancer 2023;11). |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05973487 | Phase I | TSC-200-A0201 + TSC-204-C0702 TSC-203-A0201 TSC-201-B0702 + TSC-204-A0201 TSC-200-A0201 TSC-204-A0101 + TSC-204-A0201 TSC-201-B0702 TSC-201-B0702 + TSC-204-C0702 TSC-204-A0101 TSC-204-A0101 + TSC-204-C0702 TSC-204-A0201 + TSC-204-C0702 TSC-200-A0201 + TSC-204-A0201 TSC-204-C0702 TSC-203-A0201 + TSC-204-C0702 TSC-204-A0201 TSC-203-A0201 + TSC-204-A0201 TSC-201-B0702 + TSC-204-A0101 TSC-201-B0702 + TSC-203-A0201 TSC-200-A0201 + TSC-204-A0101 TSC-200-A0201 + TSC-203-A0201 TSC-203-A0201 + TSC-204-A0101 TSC-200-A0201 + TSC-201-B0702 | A Basket Study of Customized Autologous TCR-T Cell Therapies in Patients With Locally Advanced (Unresectable) or Metastatic Solid Tumors | Active, not recruiting | USA | 0 |