Therapy Detail
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| Therapy Name | Carboplatin + Sacituzumab tirumotecan |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Carboplatin | Paraplatin | CBDCA | Chemotherapy - Platinum 7 | Paraplatin (carboplatin) is a second-generation platinum compound and is activated intracellularly to form reactive platinum complexes that cross link DNA with DNA and with proteins. This induces apoptosis and inhibits cell growth (NCI Drug Dictionary). |
| Sacituzumab tirumotecan | SKB 264|SKB-264|ADC SKB264|MK-2870|MK 2870|MK2870|SKB264 | TROP2 Antibody 18 | Sacituzumab tirumotecan (SKB264) is an antibody-drug conjugate (ADC) composed of a monoclonal antibody that targets trophoblast cell surface protein 2 (TROP2) linked to a topoisomerase I inhibitor, which delivers the drug to TROP2-expressing tumor cells, potentially resulting in antitumor activity (PMID: 41276258, Cancer Res (2024) 84 (7_Supplement): CT038). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT05816252 | Phase II | Osimertinib + Sacituzumab tirumotecan Carboplatin + Sacituzumab tirumotecan Carboplatin + Pembrolizumab + Sacituzumab tirumotecan Pembrolizumab + Sacituzumab tirumotecan Sacituzumab tirumotecan | A Study of SKB264 (MK-2870; Sac-TMT) for the Treatment of Participants With Advanced or Metastatic Non-small Cell Lung Cancer (SKB264-II-04) (MK-2870-003) | Active, not recruiting | TUR | ROU | ESP | 3 |
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