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Drug Name | SKB264 |
Trade Name | |
Synonyms | SKB 264|SKB-264|ADC SKB264|MK-2870|MK 2870|MK2870|Sacituzumab tirumotecan |
Drug Descriptions |
SKB264 is an antibody-drug conjugate (ADC) composed of a monoclonal antibody that targets trophoblast cell surface protein 2 (TROP2) linked to a topoisomerase I inhibitor, which delivers the drug to TROP2-expressing tumor cells, potentially resulting in antitumor activity (Cancer Res (2024) 84 (7_Supplement): CT038). |
DrugClasses | TROP2 Antibody 13 |
CAS Registry Number | 2768350-77-0 |
NCIT ID | C166409 |
Therapy Name | Drugs | Efficacy Evidence | Clinical Trials |
---|---|---|---|
Capecitabine + Pembrolizumab + SKB264 | Capecitabine Pembrolizumab SKB264 | 0 | 1 |
Carboplatin + Pembrolizumab + SKB264 | Carboplatin Pembrolizumab SKB264 | 0 | 1 |
Carboplatin + SKB264 | Carboplatin SKB264 | 0 | 1 |
Fluorouracil + Leucovorin + SKB264 | Fluorouracil Leucovorin SKB264 | 0 | 1 |
Fluorouracil + Pembrolizumab + SKB264 | Fluorouracil Pembrolizumab SKB264 | 0 | 1 |
Osimertinib + SKB264 | Osimertinib SKB264 | 0 | 1 |
Paclitaxel + SKB264 | Paclitaxel SKB264 | 0 | 1 |
Pembrolizumab + SKB264 | Pembrolizumab SKB264 | 0 | 6 |
SKB264 | SKB264 | 0 | 7 |