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Drug Name SKB264
Trade Name
Synonyms SKB 264|SKB-264|ADC SKB264|MK-2870|MK 2870|MK2870|Sacituzumab tirumotecan
Drug Descriptions

SKB264 is an antibody-drug conjugate (ADC) composed of a monoclonal antibody that targets trophoblast cell surface protein 2 (TROP2) linked to a topoisomerase I inhibitor, which delivers the drug to TROP2-expressing tumor cells, potentially resulting in antitumor activity (Cancer Res (2024) 84 (7_Supplement): CT038).

DrugClasses TROP2 Antibody 10
CAS Registry Number 2768350-77-0
NCIT ID C166409

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Therapy Name Drugs Efficacy Evidence Clinical Trials
Capecitabine + Pembrolizumab + SKB264 Capecitabine Pembrolizumab SKB264 0 1
Carboplatin + Pembrolizumab + SKB264 Carboplatin Pembrolizumab SKB264 0 1
Carboplatin + SKB264 Carboplatin SKB264 0 1
Fluorouracil + Leucovorin + SKB264 Fluorouracil Leucovorin SKB264 0 1
Fluorouracil + Pembrolizumab + SKB264 Fluorouracil Pembrolizumab SKB264 0 1
Osimertinib + SKB264 Osimertinib SKB264 0 1
Paclitaxel + SKB264 Paclitaxel SKB264 0 1
Pembrolizumab + SKB264 Pembrolizumab SKB264 0 6
SKB264 SKB264 0 7


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