Therapy Detail
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| Therapy Name | Daromun + Onfekafusp alfa |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Daromun | L19-IL2/L19-TNF-alpha|Darleukin/Fibromun|L19IL2/L19TNF | Daromun consists of a mixture of darleukin, a recombinant IL2 linked to the fibronectin extra domain B (EDB) targeting single-chain variable fragment (L19), and fibromun, a human TNF-alpha linked to L19, which binds to cells expressing fibronectin EDB in tumor neovasculature, potentially resulting in the induction of antitumor immune response against tumor cells expressing EDB-containing fibronectin (NCI Drug Dictionary). | ||
| Onfekafusp alfa | Fibromun|L19-TNF-alpha|L19TNF | Onfekafusp alfa comprises TNFalpha linked to a single chain variable fragment targeting fibronectin extra-domain B, which may increase antitumor immune response (NCI Drug Dictionary). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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- Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT02938299 | Phase III | Daromun + Onfekafusp alfa | Neoadjuvant L19IL2/L19TNF- Pivotal Study (Pivotal) | Active, not recruiting | POL | ITA | FRA | DEU | 0 |
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