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Therapy Name 5F11-28Z CAR-T cells
Synonyms
Therapy Description

5F11-28Z CAR-T cells are T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting TNFRSF8 (CD30) that contains CD28 hinge, transmembrane, and co-stimulatory domains, and a CD3 activation domain, which may inhibit growth of TNFRSF8 (CD30)-expressing tumor cells (PMID: 33287637).

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Drug Name Trade Name Synonyms Drug Classes Drug Description
5F11-28Z CAR-T cells 5F11-28Z T cells|5F11-Ts 5F11-28Z CAR-T cells are T-lymphocytes engineered to express a chimeric antigen receptor (CAR) targeting TNFRSF8 (CD30) that contains CD28 hinge, transmembrane, and co-stimulatory domains, and a CD3 activation domain, which may inhibit growth of TNFRSF8 (CD30)-expressing tumor cells (PMID: 33287637).

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT03049449 Phase I Cyclophosphamide + Fludarabine 5F11-28Z CAR-T cells T Cells Expressing a Fully-Human Anti-CD30 Chimeric Antigen Receptor for Treating CD30-Expressing Lymphomas Completed USA 0


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