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Therapy Name | Sargramostim + Tebentafusp |
Synonyms | |
Therapy Description | |
Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
---|---|---|---|---|
Sargramostim | Leukine | GM-CSF|Prokine | ||
Tebentafusp | Kimmtrak | ImmTAC-gp100|Tebentafusp-tebn|IMCgp100 | Kimmtrak (tebentafusp) is a gp100 antigen-specific human T-cell receptor (TCR) linked to an anti-CD3 antibody fragment, which activates cytotoxic immune response against gp100-expressing tumor cells (PMID: 24531387, PMID: 31336704, PMID: 32816891). Kimmtrak (tebentafusp) is FDA approved for use in HLA-A*2:01-positive metastatic or unresectable uveal melanoma patients. |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
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Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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NCT06626516 | Phase Ib/II | Tebentafusp Sargramostim + Tebentafusp Carmustine + Tebentafusp | Tebentafusp-tebn With LDT in Metastatic UM | Not yet recruiting | USA | 0 |