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Therapy Name [177]Lu-OncoFAP-23 + Darleukin
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Darleukin L19-IL2|L19IL2|bifikafusp alfa Darleukin is an immunocytokine comprising a recombinant antibody targeting the ED-B domain of fibronectin fused to human IL-2, which delivers the cytokine to developing blood vessels in the tumor and may induce an anti-tumor immune response (PMID: 11861281).
[177]Lu-OncoFAP-23 177Lu-OncoFAP-23 [177]Lu-OncoFAP-23 is a radioconjugate comprising a FAP ligand linked to Lutetium-177, which delivers radiation to FAP-expressing tumor cells and potentially inhibits tumor growth (PMID: 39266289).

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT06640413 Phase I [177]Lu-OncoFAP-23 + Darleukin [177]Lu-OncoFAP-23 A Study to Evaluate the Safety and Preliminary Signs of Efficacy of [177Lu]Lu-OncoFAP-23 Alone or in Combination with L19-IL2 As a Treatment of Metastatic FAP-positive Solid Tumors (Theratri) Not yet recruiting ITA 0


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