Therapy Detail
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| Therapy Name | Belantamab mafodotin-blmf + Dexamethasone + Iberdomide |
| Synonyms | |
| Therapy Description | |
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| Drug Name | Trade Name | Synonyms | Drug Classes | Drug Description |
|---|---|---|---|---|
| Belantamab mafodotin-blmf | Blenrep | anti-BCMA ADC GSK2857916|J6M0-mcMMAF|GSK2857916 | TNFRSF17 Antibody 22 | Blenrep (belantamab mafodotin-blmf) is an antibody-drug conjugate comprising an antibody targeting BCMA linked to monomethyl auristatin F, which delivers the anti-microtubule agent to BCMA-expressing tumor cells, potentially resulting in increased tumor cell death and decreased tumor growth (PMID: 30442502, PMID: 24569262). Blenrep (belantamab mafodotin-blmf) in combination with Velcade (bortezomib), and Dexamethasone is FDA-approved for adult patients with relapsed or refractory multiple myeloma who have received at least two prior lines of therapy (FDA.gov). |
| Dexamethasone | Adexone | Desametasone | ||
| Iberdomide | CC220|CC-220|CC 220 | Iberdomide (CC-220) binds to the ubiquitin E3 ligase complex member Cereblon (CRBN), which may lead to increased ubiquitination and degradation of transcription factors, resulting in decreased B-cell proliferation (PMID: 29945920, PMID: 28848067, PMID: 31719682). |
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| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|
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| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
|---|---|---|---|---|---|---|
| NCT06232044 | Phase Ib/II | Belantamab mafodotin-blmf + Dexamethasone + Iberdomide Belantamab mafodotin-blmf + Dexamethasone Belantamab mafodotin-blmf + Iberdomide | Testing the Combination of Two Approved Drugs and One Experimental Drug in Patients With Relapsed or Refractory Multiple Myeloma | Suspended | USA | 0 |
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