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Therapy Name Dinutuximab + Expanded gamma delta T-cells + Irinotecan + Temozolomide + Zoledronic acid
Synonyms
Therapy Description

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Drug Name Trade Name Synonyms Drug Classes Drug Description
Dinutuximab Unituxin MOAB Ch14.18 GD2 Antibody 6 Unituxin (dinutuximab) is a monoclonal antibody that targets B4GALNT1 (GD2) and increases antibody-dependent and complement-dependent cytotoxicity against GD2-expressing tumor cells (PMID: 26917818). Unituxin (dinutuximab) is FDA approved for pediatric high-risk neuroblastoma (FDA.gov).
Expanded gamma delta T-cells Ex vivo-expanded allogeneic gamma 9 delta 2 T-cells Expanded gamma delta T-cells are gamma delta T-cells expanded from allogeneic peripheral blood mononuclear cells stimulated with IL-2 and zoledronate, which may induce tumor cell killing and inhibit tumor growth (PMID: 35371623).
Irinotecan Camptosar CPT-11 TOPO1 inhibitor 11 Camptosar (irinotecan) inhibits Topoisomerase-I activity, resulting in inhibition of DNA replication, and potentially leading to cell death and is indicated as a component of first-line therapy in combination with 5-fluorouracil and leucovorin for patients with metastatic or recurrent colorectal carcinoma (FDA.gov).
Temozolomide Temodar Methazolastone|TMZ Chemotherapy - Alkylating 18 Temodar (temozolomide) is a dacarbazine analog and cytotoxic alkylating agent (NCI Drug Dictionary).
Zoledronic acid Zometa zoledronate

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries
NCT05400603 Phase I Dinutuximab + Expanded gamma delta T-cells + Irinotecan + Temozolomide + Zoledronic acid Allogeneic Expanded Gamma Delta T Cells With GD2 Chemoimmunotherapy in Relapsed /Refractory Neuroblastoma or Refractory/ Relapsed Osteosarcoma (Aflac-NBL-2002) Recruiting USA 0


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